2010 Oct 30;24(20):3011-20. n) Yang X, Doerge DR, Fisher JW. Epub 2014 Feb 4. c) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. [103], BPA is an environmental contaminant of emerging concern. [90] BPA binding to ERR- preserves its basal constitutive activity. At that time, another synthetic compound, diethylstilbestrol, was determined to be more powerful than estrogen itself, so bisphenol A was not used as a synthetic estrogen. This allows exposure to be easily determined by urine testing, facilitating convenient biomonitoring of populations. It was originally produced from coal tar and was named carbolic acid. Among the various polymers available as resins for composites [26][27][28][29][30][31], epoxy resins are chosen because of their excellent adhesion to many substrates and their high thermal and . For example, FDA has participated with Health Canada in encouraging industry efforts to refine their manufacturing methods for the production of infant formula can linings to minimize migration of BPA into the formula. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. Studying this sort of longterm, lowdose interaction is difficult, and although there have been numerous studies, there are considerable discrepancies in their conclusions regarding the nature of the effects observed as well as the levels at which they occur. Use the browser controls to adjust the font size, or print this page. These materials are much more common but their BPA content will be low. just looking for general information about environmental health research or the institute, this page will help. Reprod Toxicol. Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR. Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. This process, also known as a one-step process, is commonly used for the preparation of low and medium molecular weight bisphenol A epoxy resins. National Advisory Environmental Health Sciences Council - Day 1. BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . Chemical name (IUPAC): 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1 -chloro-2,3-epoxypropane, esters with acrylic acid . 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Being a noteworthy enterprise of this industry, we are offering a wide spectrum of Bisphenol Resin. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. [74] These interactions are all very weak, but exposure to BPA is effectively lifelong, leading to concern over possible cumulative effects. [90] It can also protect it from deactivation from the SERM 4-hydroxytamoxifen (afimoxifene). [9][10] For epoxy resin, it is first converted to its diglycidyl ether (usually abbreviated BADGE or DGEBA). Hot Sale CAS No 80-05-7 BPA Solid Bisphenol a for Epoxy Resin Price in Stock FOB Price: US$ 1900-2200 / Ton Min. . Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. . Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. In fact, the Federal Trade Commission has specifically cautioned that free-of claims may deceive consumers by falsely suggesting that the marketer has improved the product by removing the substance.. Dianin in 1891. Bisphenol A was investigated in the 1930's during the search for synthetic estrogens. Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. The health effects of BPA have been the subject of prolonged public and scientific debate. Bisphenol A epoxy resin is the most common type for concrete coatings because of its excellent adhesion, toughness, abrasion resistance, and chemical resistance. Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model. Learn how outdoors and chemistry work together. BPA is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and . [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. Food Additives & Petitions. Bisphenol Resin. bisphenol A: [noun] an industrial chemical compound C15H16O2 that is a component especially of hard plastics (such as polycarbonate) and epoxy resins. [21] BPA has been investigated by public health agencies in many countries, as well as by the World Health Organization. The .gov means its official.Federal government websites often end in .gov or .mil. Bisphenol-A Based Epoxy Vinyl Ester Resins Home Bisphenol-A Based Epoxy Vinyl Ester Resins VE resins are a combination of both polyester resin and epoxy resins best properties. [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. bisphenol A type Epoxy resin depending on the molecular weight and degree of polymerization n, the resin is yellow to amber transparent viscous liquid (or solid), the average molecular weight in the production of 300~700, n; 2, softening point below 50 is called low molecular weight epoxy resin (I. E. Soft resin); Molecular weight above 1000, n>2, those having a softening point above 60 C. The studies reviewed were published or available from November 1, 2009 to July 23, 2013. These meetings are listed in the NIEHS Events Calendar and are open to the general public. While air, dust, and water are other possible sources of exposure, BPA in food and beverages accounts for the majority of daily human exposure. . 2010 Dec 15;199(3):372-6. j) Ferguson SA, Law CD Jr, Abshire JS. This petition demonstrated, from publicly available information and information collected from industry sources, that the use of BPA-based epoxy resins as coatings in packaging for infant formula had been abandoned. Toxicol Appl Pharmacol. The results of the independent evaluations were released in April 2010, as FDA made the CFSAN report and other relevant information available for public comment. By 2009, FDA released reassessments of studies cited in the NTP Monograph in addition to other relevant studies that became available after the Monographs release. Polycarbonate drinks containers are also a source of exposure, although most disposable drinks bottles are actually made of PET, which contains no BPA. [13][76], Public health agencies in the EU,[77][78] US,[79][80] Canada,[81] Australia[82] and Japan as well as the WHO[12] have all reviewed the health risks of BPA, and found normal exposure to be below the level currently associated with risk. It can also be used in the formation of solid polymeric electrolyte for potential application in electrochemical devices. In July, 2012, FDA took this action in response to a food additive petition filed by the American Chemistry Council (ACC) [9]. BPA is regularly used to strengthen products for human health and safety. Its chemical formula is (CH3)2C (C6H4OH)2. [28], The synthesis of BPA still follows Dianin's general method, with the fundamentals changing little in 130 years. Epoxy resin is a polymer with the molecular formula (C11H12O3)n, which is a general term for a class of polymers containing more than two epoxy groups in the molecule. 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. [9][10] The manufacturing of epoxy resins and vinyl ester resins account for 2530% of BPA use. 2005 2022 American Chemistry Council, Inc. [1]U.S. Food and Drug Administration, Draft Assessment of Bisphenol A for Use in Food Contact Applications, 14 August 2008. Scientific research shows that in humans, BPA is quicklymetabolized and eliminated from the body it does not accumulate in blood or tissues. Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. Although many studies have been performed, these often focus on a limited range of model organisms and can use BPA concentrations well beyond environmental levels. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be made with BPA. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity, similar to glass. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. Toxicol Sci. The conclusion is not based simply on the number of studies, but more importantly on their quality and scientific value. Bisphenol A | C15H16O2 | CID 6623 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. To improve the compatibility between flame retardant and epoxy resin (EP) matrix, amino phenyl copper phosphate-9, 10-dihydro-9-oxygen-10-phospha-phenanthrene-10-oxide (CuPPA-DOPO) is synthesized through surface grafting, which is blended with EP matrix to prepare EP/CuPPA-DOPO composites. Products like bike helmets, police shields, reading glasses and bullet-proof glass are all shatter resistant because of BPA. [38][39][40] Spectroscopic data is available from AIST.[41]. An official website of the United States government. Neurotoxicol Teratol. The ACC mark, Responsible Care, the hands logo mark, CHEMTREC, TRANSCAER, and americanchemistry.com are registered service marks of the American Chemistry Council, Inc. May also be known as: Polycarbonate, Epoxy Resins. 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